Ethylene Glycol 107-21-1 Hazard Summary Ethylene glycol has many uses, including as antifreeze in cooling and heating systems, in hydraulic brake fluids, and as a solvent. Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects: central nervous system (CNS) depression, followed by
Ethylene glycol is used as a raw material in the production of polyethylene terephthalate, in antifreeze, as a gas hydrate inhibitor in pipelines, and for many other industrial applications. It is metabolized by aerobic microbial processes via the highly toxic intermediates glycolaldehyde and glycolate through C2 metabolic pathways. …
Ethylene glycol is rapidly absorbed from the gastrointestinal tract, with peak absorption in 1–4 hours and a serum half-life of 3 hours. Approximately 50% of ingested ethylene glycol is excreted unchanged by the kidneys; however, a series of oxidation reactions in the liver and kidneys metabolizes the remaining ethylene glycol.
The initial diagnosis of ethylene glycol poisoning is difficult and poisoning with ethylene glycol is rare but life threatening and needs rapid recognition and early treatment. Therefore, intoxication with ethylene glycol should not be misdiagnosed as lactic acidosis in patients with metabolic acidosis and elevated lactate levels.
62 for ethylene glycol, m/z 75 for diethylene glycol and m/z 58 for 1,3-propane diol. The FDA method applies a formula to obtain the estimate for a semi-quantitative analysis for target analytes. In this case, Xcalibur software was used to calculate the spiked samples against the high
Introduction. Ethylene glycol is a colorless, odorless, and water-soluble substance. It is currently used as a raw material in solvents, antifreezes, diluents, and various chemicals1).It is referred to as a "sweet killer" in the West because it is sweet and does not irritate the oral mucosa when ingested2).Ethylene glycol poisoning often …
Putney et al. reported that spray-freeze-dried microparticles with a single-micron size (preferably under 5 μm) of human growth hormone could be useful intermediates for microencapsulation by S/O/W emulsion [10].This may be due to the good dispersion characteristics of such small microparticles in the organic phase.
To demonstrate the sustainable production of ethylene glycol, we developed an integrated system to produce ethylene glycol from CO 2 directly instead of from …
The "GCC and Africa Ethylene Glycol Monostearate Market" is set to expand significantly, expected to hit USD xx.x Billion by 2031, with a compound annual growth rate (CAGR) of xx.
Incubation of these pastes at 37°C, surrounded by aqueous fluid leads to thermoresponsive liquid sintering and the formation of porous solid constructs [22][23][24][25][26][27].
Ethylene glycol is a colorless and odorless, high boiling point, hygroscopic liquid completely miscible with water and many organic liquids (Matar and Hatch, 2001; Speight, 2002). Mono-ethylene glycol (MEG) is the most important type of ethylene glycol. Di-ethylene glycol (DEG) and tri-ethylene glycol (TEG) glycol are obtained
Glycol and diol compounds are used to solubilize active ingredients for use in many consumer products, including cosmetics, ballpoint pen inks, wood stains, and lacquers.
Discussion. Ethylene glycol is an odorless, sweet-tasting liquid used in industrial solutions such as antifreeze, windshield wiper fluid, brake fluid, and industrial products because of its low cost [].While children sometimes accidentally consume ethylene glycol due to its sweet taste, adults tend to ingest it intentionally as …
SABIC is a market leader in key products such as ethylene, ethylene glycol, methanol, MTBE, polyethylene and engineering plastics and its derivatives. Petrochemicals, SABIC's largest strategic business unit, accounts for the bulk of the company's total production.
A review article on ethylene glycol (EG), a versatile chemical intermediate derived from fossil fuels and biomass resources. It covers the physical …
A three-stage theory of ethylene glycol poisoning was introduced in the 1950s (Berman et al. 1957; Kahn and Brotchner 1950). These stages are theoretical descriptions of ethylene glycol poisoning, but the onset and progression of the clinical course is frequently not consistent or predictable.
Upon ingestion ethylene glycol (EG, monoethylene glycol) is rapidly absorbed from the gastrointestinal tract, and depending on the severity of exposure signs of toxicity may progress through three stages. Neurological effects characterize the first step consisting of central nervous depression (into …
1. Introduction. Ethylene glycol (EG) is an important chemical that has a wide range of industrial applications. EG can be directly used as an anti-freezing agent or a coolant, and it is also a substrate to produce polymers such as polyethylene terephthalate (PET) [1].Over 25 million tons of PET are synthesized annually for the manufacturing of …
ETHYLENE GLYCOL EGL 9.20 SATURATED LIQUID DENSITY Temperature (degrees F) Pounds per cubic foot 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 70.129 69.910 69.690 69.459 69.209 68.959 68.690 68.419 68.129 67.830 67.520 67.200 66.870 66.530 66.179 65.820 65.440 65.059 9.21 LIQUID HEAT CAPACITY …
DOI: 10.1016/J.CEP.2010.09.014 Corpus ID: 96776774; Micronization of polyethylene glycol by PGSS (Particles from Gas Saturated Solutions)-drying of aqueous solutions @article{Martn2010MicronizationOP, title={Micronization of polyethylene glycol by PGSS (Particles from Gas Saturated Solutions)-drying of aqueous solutions}, …
Poly(ethylene glycol) (PEG) is widely used as a gold standard in bioconjugation and nanomedicine to prolong blood circulation time and improve drug efficacy. The conjugation of PEG to proteins, peptides, oligonucleotides (DNA, small interfering RNA (siRNA), microRNA (miRNA)) and nanoparticles is a well-established …
Ethylene glycol is the main ingredient in many antifreeze mixtures for automobile radiators. The two OH groups lead to extensive intermolecular hydrogen bonding. This results in a high boiling point—198°C; thus ethylene glycol does not boil away when it is used as an antifreeze. It is also completely miscible with water.
Poly(ethylene glycol) (PEG) as gold standard has been extensively conjugated to diagnostic and therapeutic agents or decorated on the surface of nanoplatforms, which is known as PEGylation. After the PEGylation, these formations are expected to achieve superior diagnostic and therapeutic effects. However, in-depth …
serum ethylene glycol levels exceed 50 mg/dL (8.1 mmol/L), severe acidemia (pH <7.25) or fluid/electrolyte disturbances persist despite ethanol or fomepizole therapy, vital signs continue to deteriorate despite intensive supportive treatment, or; renal failure develops.
Common moisturizers and sweeteners in toothpaste are propylene glycol, sorbitol, and glycerin. Diethylene glycol (DEG) is an organic solvent often used in antifreeze [1,2], and …
Ethylene glycol is highly poisonous; animals or humans that drink the solution become very ill and may die. In addition to its use in antifreeze, ethylene glycol is used as an ingredient in hydraulic fluids, …
Ethylene glycol, an essential commodity chemical, is widely employed as polyester fibre precursor, antifreeze, coolant and energy carrier 1,2.The global production of ethylene glycol exceeded 40 ...
Physicochemical properties of ethylene glycol. Ethylene glycol with the formula CH 2 OH 2, also known as 1,2-ethanediol, is a popular organic compound.The safety data sheet for ethylene glycol, as well as for other substances, is the primary source of information on their physical and chemical properties. Ethylene glycol is the main …
Affiliations 1 Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China. [email protected].; 2 School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China. …
The analytical method described here enables the determination of Occupational Exposure Limits (OEL) or MAK values for ethylene glycol, diethylene glycol and propylene glycol in workplace air …
We verified our active-site redesign with an atomic-resolution, 1.96-Å cryo-electron microscopy structure and engineered two more enzymes that, together with GCC, form a carboxylation module...
Ethylene glycol is converted to glycolaldehyde by alcohol dehydrogenase (ADH), an enzyme that also catalyzes the first, rate-limiting step in the metabolism of methanol and ethanol. 5 Glycolaldehyde is subsequently converted to glycolic acid, then to glycoxylic acid, and finally to oxalic acid. Glycolic acid is cytotoxic and produces …
To this end, poly(ethylene glycol) (PEG) was assessed as a micronizing and solubilizing agent for dry protein encapsulation and release from electrosprayed particles made from …
Methanol and ethylene glycol poisonings cause scores of fatal intoxications annually, and even relatively small ingestions of these alcohols can produce significant toxicity. Rapid recognition and early treatment, including alcohol dehydrogenase (ADH) inhibition and often hemodialysis, are crucial.
Ethylene glycol is a synthetic liquid substance that absorbs water.� Ethylene glycol is used to make antifreeze and de-icing solutions for cars, airplanes, and boats.� It is an ingredient in hydraulic brake fluids and in inks used in stamp pads, ballpoint pens, and print shops.� It is a solvent used in the paint and plastics industry, and is used to produce …
Affiliation 1 DDS Research Department, Discovery Research Laboratory, Tanabe Seiyaku Co. Ltd., 3-16-89 Kashima, Yodogawa-ku, 532-8505, Osaka, Japan. t-morita@tanabe