Sticking is one of the most common problems tablet manufacturers encounter. Sticking describes the buildup of granules on the punch-tip face, which can be caused by several factors, including the formulation's physicochemical properties and the surface characteristics of the punch face. Because sticking is such a universal problem for …
Tabletting Science® restoring the optimum finish of the tooling, problems like sticking or picking can be prevented. Poor tablet design: Problem Insufficient tablet compaction is another cause of sticking. In a tablet with decreased hardness, the cohesive force can be less than the adhesive force to the tooling surface.
The manufacturing process being used will determine how many options are available to help reduce sticking. For example, a direct-compression process will have fewer processing levers to pull than a wet-granulation process. ... Angela Olsofsky, Wyatt J. Roth, and Mike Tobyn, "Sticking and picking in pharmaceutical tablet compression: An IQ ...
A good cleaning regime goes hand in hand with a good polishing regime, which forms Step 5 of the process and is arguably the next most critical step. It is cleaning and polishing that deliver most noticeable benefit into production, reducing tablet press down time and helping to increase productivity.
In bulk behaviour, however, when lots of these forces interact on the face of a tablet, they can cause sticking. Capillary action. Another major influencer of sticking is capillary action, which can be linked to high moisture content. If moisture is present, there is the potential for sticking in both direct compression or wet granulation.
Worn tips can result in poor quality tablets and inferior embossing definition that can lead to picking and sticking. Repair should be carried out by well-trained and experienced maintenance technicians to ensure that the tooling does not exceed tolerance limits. ... thereby helping to maximize tooling life and reduce problems such as sticking ...
Learn about the causes and solutions of sticking and picking, common defects in tablet manufacturing. Pre-picking is a special engraving feature that reduces picking …
When a sticking defect is noticed on a tablet, one must first identify where the sticking is occurring (upper punch, lower punch or both). The location of the sticking/picking will help in identifying the root cause. There are as many causes of sticking and picking as there are formulations. A few of the most common are …
reducing the overall stroke depth of the embossing and will assist you in keeping a clear brand identity. 'Sticking' of course is another major issue in the design and manufacture of tablets. Sticking differs to picking in that it is gran ule adherence to the punch tip face, rather than in and around the embossing.
Sticking or picking issues are often not detected until transferring the product from research and development to production. Possible causes. Although sticking and picking are frequently related to deficiencies in tablet design, remediation does not always require changing the design (and thus the tools used for tablet manufacturing).
Punch and die cleaning is essential for the removal of residue and to avoid product contamination and potential production issues, such as sticking and picking, caused by old product adhering to the surface of the punch tip. Cleaning also allows for an accurate assessment of tooling condition during further processes within any …
Reducing picking with font selection. When simple fixes, as mentioned above, are not enough, a full tablet and tooling design review may be necessary. Font selection is often a battle of form versus function. An ornate or decorative font, while pleasing to the eye, will likely cause picking problems and tablet defects. ... If the …
Generally, excessive moisture or humidity in the processing area will result in an increase in sticking or picking. Also, increasing the amount of lubricant in a formulation can improve product ...
1. Introduction. Powder sticking is an issue for the pharmaceutical industry because the multiple mechanisms contributing to sticking are not fully understood at a fundamental, scientific level [1], [2]. 'Sticking' refers to the adhesion of the active pharmaceutical ingredient (API) or tablet excipients to the surface of the tablet punches …
defects like sticking and picking in tabletting are paramount. Tablet defects can lead to manufacturing ... improving flow and reducing sticking during tabletting. Conversely, formulas 2 to 4 utilized
In order to increase the production rates and to secure the base production technology for the hard casting materials, a re-start casting technology as an active curing methodology has been developed to reduce the number of sticking type breakouts in the thin slab caster with high speed.
comprehensive understanding of the tablet making process in the pharmaceutical industry with this step by step guide. From selection of ingredients to inspection and packaging, this article covers all aspects of tablet production in pharma with an emphasis on quality and safety. Learn about the warnings and precautions to take …
From the sublimation behavior of IBP as seen in the Fig. 16, considering a very short time during the tabletting process, sublimation of IBP can be controlled by using the coated granules at slightly elevated temperatures, thus effectively reducing the sticking problem that may occur during compression due to a local temperature rise up to 30 ...
issues such as sticking, picking, and potential tablet defects before any tablets are produced. The first line of defence for avoiding tablet compression problems is tablet design, which should be done with input from all team members, including an experienced tooling vendor. The prepared powder formulation and compression tooling share a
A sequence of blend mixers with differing quantities of glidants and constant KETP drug formulations was prepared as illustrated in Table 1.Before sifting into the V-blender, the drug and microcrystalline cellulose 102 (MCC) were sieved through a #25 mesh size, while glidants were sieved through a #40 mesh to eliminate possible lumps …
1. Introduction. The term "punch sticking" refers to the adherence of powder material on to the tooling surface during compaction. Punch sticking is a phenomenon that commonly occurs in tablet manufacturing and is usually more severe for debossed tablets (Waimer et al., 1999a).In severe cases of sticking, obvious tablet defects, due to …
Sticking and picking are two common problems which may occur during the tablet compression operation. Most of the operators and pharmacists are confused with the term sticking and picking and they use the common term sticking for all cases. But there is a big difference between sticking and picking.
Sticking and picking during tablet manufacture has received increasing interest recently, as it causes tablet defects, downtime in manufacturing, and yield losses. The capricious nature of the problem means that it can appear at any stage of the development cycle, even when it has been deemed as low risk by models, tests, and …
Sticking is often described as the Achilles' heel of tablet production. It is one of the most common tablet tooling problems and can have a profound effect on production, leading …
Reduce granule size or optimize granulation parameters to improve the flowability of the granule. 2. ... Picking is a specific type of sticking. It occurs when the tablet material is left behind on the punch faces with embossing designs. Picking can result in tablet surface damage, incomplete tablets, or weight and appearance variations. ...
Sticking should not be confused with picking, which can look very similar to sticking, but which can commonly be resolved by changing tablet design. In recent years, I Holland has seen increasing requests for assistance in solving sticking from both generics and pharmaceutical companies alike.
In this blog post, we'll delve into the world of tableting to unravel the secrets behind sticking and picking problems. Whether you're an experienced manufacturer or just …
After you complete the compression process, you may realize that some granules are still stuck on the surface of the tablet. This may be as a result of excess moisture preventing some components from breaking down at the end of the process. Sometimes, the cracks left on the tablet allows moisture to be absorbed leading to picking.
Sticking and picking during tablet manufacture has received increasing interest recently, as it causes tablet defects, downtime in manufacturing and yield losses.
tablet defects, such as sticking and picking, which may be caused by entrapped air within the tablet press die. Formulation design, engraving, tooling material or coating can improve powder flow during the compression cycle and thus reduce tablet defects. Gentle curvature in engraving cuts results in more laminar and less turbulent powder flow.
May 2017 Summary Poor lubrication results in picking and sticking problems during production. These are one of the most common causes of tablet. pharma-excipients - News. News Feed on Excipients; ... How to reduce the risk of tablet picking and sticking. How to reduce the risk of tablet picking and sticking. 23. May 2017 .
pharmaceutical tablets. Sticking, capping and lamination are among the defects the most commonly and the most often described in the literature. Capping and lamination both refers to a problem of tablet failure after the ejection of the tablet from the die, but they, in fact, correspond to different phenomena. Capping refers to the separation
